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2025 Impact ReportOur mission is to foster science & technology innovation for a sustainable planet. 2 | Larta Institute’s 2025 Impact Report | 3 Building What’s Next 03 Programs & Metrics Impact In Action 0204 04 Foreword 3630 Financials & GovernanceCase Studies 06 Our Origins, Mission & Evolution 4034 Looking AheadPartnering with Larta 08 Our Timeline 05 2025 At a Glance 3832 Our TeamImpact Fund 11 Our Impact Thesis 12 The Translation Infrastructure 10 2025 Landscape: Why Our Work Matters Now 42 Special Acknowledgements Current Landscape 01 20 Venture Fellows 26 Global Bridge 16 Heal.LA 24 TABA 14 Our Strategic Impact Areas4 | Larta Institute’s 2025 Impact Report In Los Angeles and beyond, interconnected crises—from wildfires to widening capital gaps and shifting federal priorities—made the stakes unmistakable. The challenge is no longer invention alone. It is deployment. In response, Larta accelerated its transition from a commercialization partner to a builder of innovation infrastructure. Through our Community Labs programs, Venture Fellows and Heal.LA, we supported entrepreneurs developing solutions for climate resilience and community health—while also designing deployment pathways that connect innovation with capital and implementation partners. At the national level, we worked with initiatives from USDA and DOE. These include the USDA-funded national Meat Processors and Producers Research Initiative (MPPRI), developed with USDA, DOE-funded circular biofuels production partnerships with the City of Reedley, and exploring possible pilots with the Los Angeles Department of Water and Power. Across all Larta programs, we worked hands- on with 300 companies while expanding philanthropic partnerships and mobilizing catalytic capital where traditional pathways are narrowing. In 2025, we also helped launch new regionally aligned investment through the State of California’s California Jobs First initiative, directing $3.3 million in early-stage capital toward science-driven ventures emerging from our ecosystem. Looking ahead to 2026, we are doubling down on this ecosystem approach—strengthening resilient innovation systems that can withstand disruption and scale solutions where they matter most. The innovators we support are building the future. But they cannot do it alone. We invite our partners, funders, and policymakers to help shape what comes next. For 33 years, Larta Institute has worked at the intersection of science, capital, and community. The organization has supported more than 7,000 enterprises advancing solutions for a sustainable planet. But in 2025, one thing became clear: supporting innovation is no longer enough. We must help build the systems that allow it to reach the people who need it most. Rohit Shukla Founder & CEO Larta Institute Foreword 01 | CURRENT LANDSCAPE | 5 300 unique enterprises supported $40.7B follow-on funding raised 10 commercialization assistance and innovation hub programs designed and managed 497 targeted technical assistance engagements completed 361 technologies advanced 2025 At a Glance Translating Innovation into Impact (Since 1993) Impact by the Numbers $21.7B+ in total non-dilutive capital raised (including SBIR/STTR funding) 459+ mergers and acquisitions 50% of all Larta-supported companies generating revenue to date More than $34.3B+ in total private investment raised by Larta-supported companies 7,000+ science and technology ventures supported 38 IPOs6 | Larta Institute’s 2025 Impact Report Our Origins, Mission & Evolution OUR BEGINNINGS Larta Institute was founded in 1993 at a pivotal moment for California’s economy. As the aerospace sector declined, the State of California launched the Los Angeles Regional Technology Alliance (hence “LARTA,” now just “Larta”) to help transition the region toward entrepreneur- led growth. What began as a regional economic response quickly evolved into a national model for translating research into real-world impact. OUR MISSION Larta’s mission is to foster science and technology innovation for a sustainable planet. We work to shorten the distance between breakthrough solutions and the communities that need them most—advancing progress across food systems, energy resilience, ecology, and human health. This commitment is captured in our call to feed, fuel, and heal the world. 01 | CURRENT LANDSCAPE | 7 OUR EVOLUTION: FROM COMMERCIALIZATION SUPPORT TO TRANSLATION INFRASTRUCTURE For more than three decades, Larta has partnered with federal agencies—including DARPA, NIH, DOE, NSF, NIST, NOAA, and USDA—to help over 7,000 science-driven ventures move toward market readiness, collectively mobilizing $34B+ in dilutive capital and $21B+ in non- dilutive capital. As the innovation landscape has shifted, so has Larta’s role in that landscape. Today, Larta operates as a translation platform: strengthening pipelines, validating real solutions in communities, and mobilizing catalytic capital into sectors where traditional finance often stops short. We do more than support enterprises. We help build systems that allow high-impact innovation to develop and scale.Our Timeline: Decades of Impact 01 | CURRENT LANDSCAPE 2003 2005- 2009 19972004 First Federal PartnershipsNational Expansion Independent Nonprofit NIH CAP Launch Awarded initial commercialization contracts with NIST ATP and partnered with DARPA. Expanded partnerships with NSF and USDA and launched the Ag Innovation Showcase. Incorporated as a 501(c)(3) and launched Global Bridge to connect innovators across borders. Designed and launched the NIH Commercialization Accelerator Program, establishing national leadership and hosting 14 curated events, including training sessions, workshops, pitch days, and Demo Days in translational support for life sciences innovation. Founded Established by the State of California within LAEDC as the Los Angeles Regional Technology Alliance. 1993 8 | Larta Institute’s 2025 Impact Report2025 20202023 Catalytic Capital Platform Heal.LA Launch Regional Thought Leadership Secured $3.3M through California Jobs First to establish the Larta Impact Fund and expanded Community Labs with support from the Broad Foundation. Launched Heal.LA and introduced our Community Labs programs, creating impact hubs that advance climate resilience, health equity, and infrastructure innovation through cross- sector collaboration. Hosted the inaugural ECO Festival and published Rooted Horizons white paper on urban agriculture in Los Angeles. Feed, Fuel & Heal Framework Introduced the Feed, Fuel, and Heal framework, establishing Larta’s integrated approach to advancing innovation across food systems, energy sustainability, and health; a model that continues to shape our mission and programs today. Extended collaboration with DOE and NOAA and formalized sector focus across sustainability systems. 2014 Venture Fellows Launch Launched Venture Fellows to accelerate entrepreneur-led innovation, providing mentorship, commercialization support, and pathways to scale solutions addressing community and environmental challenges. 2022 | 9Next >